Protein Details: β2 (Calcium-activated potassium channel subunit beta-2)

Protein ID

ICDB_Pro_1718

Protein Name

β2 (Calcium-activated potassium channel subunit beta-2)

Gene Name

KCNMB2

Organism

Homo sapiens (Human)

Length

235 amino acids

AlphaFoldDB

AF-Q9Y691-F1-model_v4.pdb

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1;thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons

Sequence

MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLLRSYMQSVWTEESQCTLLNASITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGEKLLLYHTEETIKINQKCSYIPKCGKNFEESMSLVNVVMENFRKYQHFSCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR

PDB Structures

1JO6

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Epilepsy

Location

Expressed in kidney; heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.

DOI ID

10.1073/pnas.96.7.4137; 10.1074/jbc.275.9.6453; 10.1101/gr.2596504; 10.1523/jneurosci.19-13-05255.1999; 10.1073/pnas.100118597; 10.1085/jgp.20028667; 10.1152/nips.01387.2002; 10.1074/jbc.m107118200

RefSeq

NP_001265840.1; NP_005823.1; NP_852006.1; XP_011510627.1